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已发表论文

采用石墨烯 (Graphene) 平板对金相组织、机械性能的影响以及钙硅酸盐 (calcium silicate) 涂层的体内生物相容性

 

Authors Xie YT, Li HQ, Ding CX, Zheng XB, Li K

Published Date June 2015 Volume 2015:10 Pages 3855—3863

DOI http://dx.doi.org/10.2147/IJN.S77919

Received 21 November 2014, Accepted 16 February 2015, Published 8 June 2015

Approved for publication by Dr Lei Yang

Abstract: Calcium silicate (CS) ceramic is a good coating candidate for biomedical implants to improve biocompatibility and accelerate early osseo-integration. However, the poor fracture toughness and wear resistance of this ceramic material restricts the long-term performance of implants. In this study, graphene plates (GPs) were used as reinforcement to improve the mechanical properties of CS coating. Composite coating containing 1.5 weight % GPs was prepared by vacuum plasma spraying technology. The good survival of the GPs in the composite coating was demonstrated by Raman analysis, although the defects of the GPs were increased after plasma spraying. Effects of the GPs’ adoption on the microstructure of the coating were studied by scanning electron microscopy and transmission electron microscopy. Results showed that the GPs were homogenously distributed in the CS grains interface or enwrapped on the particles, and exhibited good wetting behavior with the CS matrix. The wear properties of the composite coating were obviously enhanced by the reinforcement of GPs. The reinforcement mechanism was attributed to the enhanced micro-hardness and interfacial bonding of the particles in the coating. In vivo experiments demonstrated that the composite coating possessed similarly good biocompatibility compared to pure CS coating. The bone-implant contact ratio reached 84.3%±7.4% for GPs/CS coating and 79.6%±9.4% for CS coating after 3 months’ implantation.
Keywords: graphene plates, coating, microstructure, wear resistance, biocompatibility






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