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已发表论文

预处理血浆 D-二聚体水平和血小板数量的升高预示着胰腺癌的预后不良

 

Authors Liu P, Zhu Y, Liu L

Published Date June 2015 Volume 2015:8 Pages 1335—1340

DOI http://dx.doi.org/10.2147/OTT.S82329

Received 6 February 2015, Accepted 10 March 2015, Published 4 June 2015

Approved for publication by Professor Daniele Santini

Abstract: This retrospective study was conducted to evaluate the prognostic significance of the preoperative plasma D-dimer levels and platelet counts in patients with pancreatic adenocarcinoma. A total of 168 consecutive locally advanced pancreatic adenocarcinoma patients who underwent intensity modulated radiation therapy with or without chemotherapy were enrolled in this study. Plasma D-dimer levels were measured by a latex-enhanced immunoturbidimetric assay. Of the 168 patients enrolled, 106 patients were males and 62 patients were females. There was significant difference between plasma D-dimer levels and clinical responses (P =0.001). The 1-year, 2-year, and 3-year cumulative overall survival rates were 50.6%, 15.0%, and 4.9%, respectively. Plasma D-dimer levels (P <0.001) and platelet counts (P =0.010) were significantly related with overall survival in univariate analysis. The Cox proportional hazards regression indicated that plasma D-dimer levels (P =0.028), platelet counts (P =0.004), and treatment response (P <0.001) were independent prognostic factors for overall survival. Elevated pretreatment plasma D-dimer levels and platelet counts predict poor prognosis in pancreatic adenocarcinoma.
Keywords: pancreatic adenocarcinoma, D-dimer, platelet counts, prognosis, radiotherapy






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