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已发表论文

顺利获得多巴胺 (Dopamine) 氧化自聚对 MPEG-b -PCL 聚合物纳米颗粒进行表面改性以用于恶性黑色素瘤的治疗

 

Authors Xiong W, Peng LX, Chen HB, Li Q

Published Date April 2015 Volume 2015:10 Pages 2985—2996

DOI http://dx.doi.org/10.2147/IJN.S79605

Received 19 December 2014, Accepted 18 February 2015, Published 16 April 2015

Abstract: To enhance the therapeutic effects of chemotherapy on malignant melanoma, paclitaxel (PTX)-loaded methoxy poly(ethylene glycol)-b -poly(ε-caprolactone) nanoparticles (MPEG-b -PCL NPs) that had their surfaces modified with polydopamine (PTX-loaded MPEG-b -PCL NPs@PDA) were prepared as drug vehicles. The block copolymer MPEG-b -PCL was synthesized by ring-opening polymerization and characterized by proton nuclear magnetic resonance spectroscopy and gel permeation chromatography. The PTX-loaded NPs were prepared by a modified nanoprecipitation technique. The PTX-loaded NPs and PTX-loaded NPs@PDA were characterized in terms of size and size distribution, zeta potential, surface morphology, drug encapsulation efficiency, and drug release. Confocal laser scanning microscopy showed that coumarin-6-loaded NPs@PDA could be internalized by human melanoma cell line A875 cells. The cellular uptake efficiency of NPs was greatly enhanced after PDA modification. The antitumor efficacy of the PTX-loaded NPs@PDA was investigated in vitro by the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) assay and in vivo by a xenograft tumor model. The PTX-loaded NPs@PDA could significantly inhibit tumor growth compared to Taxol® and precursor PTX-loaded NPs. All the results suggested that the PTX-loaded MPEG-b -PCL NPs that had their surfaces modified with PDA are promising nanocarriers for malignant melanoma therapy.
Keywords: cancer nanotechnology, drug delivery, surface modification, polydopamine, malignant melanoma






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