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已发表论文

miR-29b 在癌症中的作用： 调节，功能和信号传输

 

Authors Yan B, Guo Q, Fu FJ, Wang Z, Yin Z, Wei YB, Yang JR

Published Date March 2015 Volume 2015:8 Pages 539—548

DOI http://dx.doi.org/10.2147/OTT.S75899

Received 16 October 2014, Accepted 19 January 2015, Published 3 March 2015


Abstract: MicroRNAs (miRNAs) are endogenous small non-coding RNAs with the capacity to regulate gene expression post-transcriptionally. The miRNA-29 family consists of miR-29a, miR-29b, and miR-29c, among which miR-29b is the most highly expressed and is found at two genomic loci. Recently, numerous studies have demonstrated that aberrant expression of miR-29b is common in the majority of human cancers. miR-29b is known to critically affect cancer progression by functioning as a tumor suppressor. However, it may also act as an oncogene under certain conditions. In this review, we illustrate the role of miR-29b in cancer regulation, function, and signaling. This is the first review highlighting the role of miR-29b in cancer. Our review aims to summarize the effects of miR-29b on cancer activity and its interactions with target genes and signaling pathways, as well as to provide therapeutic implications for overcoming cancer chemoresistance.
Keywords: miR-29b, cancer, biological function, oncogene, tumor promoter, chemoresistance


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