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    已发表论文

    新颖的花形白蛋白颗粒作为药物受控释载体以穿透圆窗膜

     

    Authors Yu Z, Yu M, Zhou Z, Zhang Z, Du B, Xiong Q

    Published Date July 2014 Volume 2014:9(1) Pages 3193—3201

    DOI http://dx.doi.org/10.2147/IJN.S59807

    Received 27 December 2013, Accepted 10 March 2014, Published 1 July 2014

    Abstract: Controlled-release carriers for local drug delivery have attracted increasing attention for inner-ear treatment recently. In this paper, flower-shaped bovine serum albumin (FBSA) particles were prepared by a modified desolvation method followed by glutaraldehyde or heat denaturation. The size of the FBSA particles varied from 10 µm to 100 µm, and most were 50–80 µm. Heat-denatured FBSA particles have good cytocompatibility with a prolonged survival time for L929 cells. The FBSA particles were utilized as carriers to investigate the release behaviors of the model drug – rhodamine B. Rhodamine B showed a sustained-release effect and penetrated the round-window membrane of guinea pigs. We also confirmed the attachment of FBSA particles onto the round-window membrane by microscopy. The FBSA particles, with good biocompatibility, drug-loading capacity, adhesive capability, and biodegradability, may have potential applications in the field of local drug delivery for inner-ear disease treatment.
    Keywords: bovine serum albumin (BSA), controlled release, local delivery, round-window membrane






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