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      已发表论文

      可切除性胸廓食管鳞状细胞癌的淋巴结跳跃式转移的预后价值

       

      Authors Song G, Jing W, Xue S, Guo H, Yu J

      Received 10 January 2017

      Accepted for publication 2 May 2017

      Published 25 May 2017 Volume 2017:10 Pages 2729—2736

      DOI http://doi.org/10.2147/OTT.S132062

      Checked for plagiarism Yes

      Review by Single-blind

      Peer reviewers approved by Dr Ashok Kumar Pandurangan

      Peer reviewer comments 3

      Editor who approved publication: Prof. Dr. Geoffrey Pietersz

      Purpose: This study aimed to investigate the incidence of nodal skip metastasis (NSM) to identify the risk factors that influence NSM and to assess the prognostic value of NSM in patients with thoracic esophageal squamous cell carcinoma (ESCC).
      Patients and methods: Between January 2009 and December 2013, 285 patients with ESCC with positive lymph nodes who underwent complete resection were enrolled.
      Results: For the entire group, NSM occurred in 32.3% (92/285) of patients. The median survival time and 5-year survival rate in the NSM group were 28 months and 12.0%, respectively, compared with 36.3 months and 25.0%, respectively, in the non-NSM group (P =0.008). Both N stage (P =0.001) and T stage (P =0.014) were associated with the incidence of NSM. NSM (P =0.008), T stage (P =0.000), and N stage (P =0.000) were independent prognostic factors for survival. In the NSM group, T stage (P =0.014) and N stage (P =0.000) were independent prognostic factors for survival.
      Conclusion: It was concluded that NSM is common in ESCC and is associated with poor survival.
      Keywords: esophageal squamous cell carcinoma, surgery, nodal skip metastasis, incidence, risk factors, prognosis


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