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已发表论文

幽门螺杆菌感染作为中国肾结石形成的独立危险因素：一项横断面研究

 

Authors Gong R , Ling Y, Wang S, Wang W, Meng L, Zeng J, Lin R, Xu S

Received 11 March 2025

Accepted for publication 20 May 2025

Published 5 June 2025 Volume 2025:18 Pages 2881—2888

DOI http://doi.org/10.2147/IDR.S523335

Checked for plagiarism Yes

Review by Single anonymous peer review

Peer reviewer comments 2

Editor who approved publication: Prof. Dr. Héctor Mora-Montes

Rui Gong,1,* Yan Ling,1,* Shi Wang,2,* Weijun Wang,3 Lingjun Meng,3 Junchao Zeng,1 Rong Lin,3 Sanping Xu1 

1Health Management Center Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 2Department of Thyroid and Breast, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China; 3Department of Gastroenterology, Union Hospital, Tongji Medical college, Huazhong University of Science and Technology, Wuhan, 430022, People’s Republic of China

*These authors contributed equally to this work

Correspondence: Rong Lin, Department of Gastroenterology, Union Hospital, Tongji Medical college, 1277 Jiefang Avenue, Jianghan District, Wuhan, Hubei Province, 430022, People’s Republic of China, Email linrong@hust.edu.cn Sanping Xu, Health Management Center Union Hospital, Tongji Medical college, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Jianghan District, Wuhan, Hubei Province, 430022, People’s Republic of China, Email 1989XH0596@hust.edu.cn

Introduction: This cross-sectional study aimed to explore the relationship between Helicobacter pylori (Hp) infection and kidney stone formation in China, given the high incidence of Hp infection and its potential to cause damage to multiple systems.
Methods: Conducted at the Department of Health Management of Wuhan Union Hospital, the study included 48,294 hp-negative and 28,455 hp-positive individuals. Hp infection was detected using the 13C urea breath test (13C-UBT), and kidney stones were identified via urinary Doppler ultrasonography.
Results: Results showed that Hp-negative (Hp-) individuals had higher levels of blood urea nitrogen (BUN), serum creatinine (Scr), and uric acid compared to Hp-positive (Hp+) individuals, while Hp- patients had lower urine pH (P < 0.001). The prevalence of kidney stones was significantly higher in the Hp+ group. Univariate and multivariate regression analyses indicated that Hp infection is an independent risk factor for kidney stones (OR: 1.275, 95% CI: 1.219– 1.333, P < 0.001) after adjusting for confounding factors such as age, body mass index (BMI), blood pressure, and lipid profiles.
Conclusion: In conclusion, Helicobacter pylori infection is an independent risk factor for kidney stone development in China.

Keywords: Helicobacter pylori, kidney stone, urine acid, urine pH, risk factor

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