Ebpay生命医药出版社

    • Ebpay生命

    100763

    论文已发表

    提 交 论 文


    注册即可获取Ebpay生命的最新动态

    注 册



    IF 收录期刊



    • 3.3 Breast Cancer (Dove Med Press)
    • 3.4 Clin Epidemiol
    • 2.5 Cancer Manag Res
    • 2.9 Infect Drug Resist
    • 3.5 Clin Interv Aging
    • 4.7 Drug Des Dev Ther
    • 2.7 Int J Chronic Obstr
    • 6.6 Int J Nanomed
    • 2.5 Int J Women's Health
    • 2.5 Neuropsych Dis Treat
    • 2.7 OncoTargets Ther
    • 2.0 Patient Prefer Adher
    • 2.3 Ther Clin Risk Manag
    • 2.5 J Pain Res
    • 2.8 Diabet Metab Synd Ob
    • 2.8 Psychol Res Behav Ma
    • 3.0 Nat Sci Sleep
    • 1.8 Pharmgenomics Pers Med
    • 2.7 Risk Manag Healthc Policy
    • 4.2 J Inflamm Res
    • 2.1 Int J Gen Med
    • 4.2 J Hepatocell Carcinoma
    • 3.7 J Asthma Allergy
    • 1.9 Clin Cosmet Investig Dermatol
    • 2.7 J Multidiscip Healthc



    更多详情 >>





    已发表论文

    成人发病型颅咽管瘤患者患非酒精性脂肪性肝病及晚期肝纤维化的危险因素：一项横断面研究

     

    Authors Chen L, Wu W, Ye H

    Received 6 November 2024

    Accepted for publication 22 February 2025

    Published 25 March 2025 Volume 2025:18 Pages 859—871

    DOI http://doi.org/10.2147/DMSO.S504968

    Checked for plagiarism Yes

    Review by Single anonymous peer review

    Peer reviewer comments 2

    Editor who approved publication: Professor Jae Woong Sull

    Lijiao Chen, Wei Wu, Hongying Ye

    Department of Endocrinology, Huashan Hospital, Fudan University, Shanghai, 200040, People’s Republic of China

    Correspondence: Hongying Ye, Department of Endocrinology, Huashan Hospital, Fudan University, No. 12 Wulumuqi Road (Middle), Shanghai, 200040, People’s Republic of China, Email yehongying@huashan.org.cn

    Purpose: To investigate the prevalence of and risk factors for metabolic dysfunction-associated fatty liver disease (MAFLD) and advanced liver fibrosis (ALF) in postoperative adult-onset craniopharyngioma (AOCP) patients.
    Patients and Methods: This cross-sectional study included 242 postoperative AOCP patients at Huashan Hospital (Shanghai, China). Clinical characteristics were compared between patients with and without MAFLD and ALF. Independent risk factors for MAFLD and ALF were identified using binary logistic regression analysis.
    Results: The prevalence of MAFLD in postoperative AOCP patients was 67.4% (95% CI 61.2– 73.0%), and 32.5% (95% CI 25.8– 40.0%) of patients with MAFLD were diagnosed with ALF. Body mass index (BMI) was independently associated with MAFLD (OR = 1.51, 95% CI 1.33– 1.72, P < 0.001). In patients with MAFLD, hypertension (OR = 2.33, 95% CI 1.04– 5.20, P = 0.040), glycated hemoglobin (HbA1c) (OR = 1.34, 95% CI 1.01– 1.78, P = 0.044), daily hydrocortisone dose (OR = 1.08, 95% CI 1.01– 1.15, P = 0.026), and insulin-like growth factor-1 (IGF-1)(OR = 0.99, 95% CI 0.97– 0.99, P = 0.011) were independently associated with the presence of ALF.
    Conclusion: MAFLD is a common comorbidity in postoperative AOCP patients and is associated with a high risk of ALF. MAFLD is closely related to BMI, while ALF is significantly associated with hypertension, HbA1c levels, IGF-1 levels, and daily hydrocortisone dose. Strategies such as controlling weight gain, maintaining optimal blood glucose and blood pressure levels, appropriate hormone replacement, and avoiding excessive glucocorticoid use should be implemented to prevent and delay the onset and progression of MAFLD and ALF.

    Keywords: craniopharyngioma, adult-onset, hypopituitarism, metabolic dysfunction-associated fatty liver disease, advanced liver fibrosis

    Download Article[PDF]